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Using gold nanoparticles in manufacturing LSPR kit for detection of biomolecules

News Date : 2016-12-11 News Visited Count : 934
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In response to the domestic demands, "nanomabna Iranian" knowledge-based company has recently managed to produce LSPR kit for detection of biomolecules. It operates based on the surface plasmon resonance (SPR) of gold nanoparticles which makes it capable of detecting small amounts of biomolecules. The kit is best suited for rapid, accurate, easy and cost effective detection of low concentrations of biomolecules using small samples.
In response to the domestic demands, "nanomabna Iranian" knowledge-based company has recently managed to produce LSPR kit for detection of biomolecules. It operates based on the surface plasmon resonance (SPR) of gold nanoparticles which makes it capable of detecting small amounts of biomolecules. The kit is best suited for rapid, accurate, easy and cost effective detection of low concentrations of biomolecules using small samples.
The designed kit is suitable for research in interdisciplinary fields of science, engineering and medicine. Gold and silver nanoparticles which are the main sensors used in the kit are homogenously incorporated at 25 separate holes on the kit resulting in 1 nm accuracy in plasmon resonance wavelength.
Therefore, the kit provides uniform sensing space for accurate comparative studies and investigating the kit response to considered analytes. For example, the kit response to different concentrations of the studied material can be readily evaluated and negative controls can be determined. Localized surface plasmon resonance (LSPR) phenomenon is the resonant oscillation of free electrons at the interface of metal nanoparticles and biomolecules. This detecting method which has attracted the interest of researchers in interdisciplinary fields of physics, chemistry and biology is more advanced and of course more accurate than conventional detecting methods. Nowadays, application of this phenomenon in characterization and detection of materials, chemical compounds and biological molecules is of high interest to a large number of researchers. The advantages of the proposed method include rapid accurate detection of low and high concentrations of biomolecules, distinguishing weak reaction between biomolecules, simultaneous detection of various biological factors, long life of solid state biochips, cost efficiency and temperature insensitivity of the method.
Depositing highly ordered arrays of gold nanoparticles with a uniform morphology and particle size less than 5 nm on the kit as well as capability of detecting different amounts of various biomolecules are also distinct properties of the product.
The manufactured kit can be readily used in a wide range of applications including detection of biomarkers for diagnosing cancer, detection of biomolecular reactions in medicine, sequence detection, identifying the genetic disorder and mutation, detection of viruses as well as bacteria and toxins, measuring glucose level in diagnosing diabetes, detecting exhale gases for diagnosis of lung diseases as well as detecting air pollutants, carbon monoxide, sulfur compounds and narcotics.
The kit has received the NanoScale certificate from the product evaluation unit of Iran nanotechnology initiative council.

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